Clinical Trial: SCN9A Gene Expression and Inflammatory Cytokines

U.S., April 16 -- ClinicalTrials.gov registry received information related to the study (NCT07532200) titled 'SCN9A Gene Expression and Inflammatory Cytokines' on April 08.

Brief Summary: Voltage-gated sodium channels, especially Nav1.7 encoded by the SCN9A gene, are key regulators of nociceptive transmission. Upregulation of SCN9A has been associated with increased neuronal excitability and heightened pain perception. In parallel, inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) are known to sensitize peripheral nociceptors and reduce the efficacy of local anesthetics by modifying tissue environment and ion channel activity. However, the combined influence o...