U.S., Aug. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07745036) titled 'Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia' on July 29.
Brief Summary: Preeclampsia is a pregnancy-specific hypertensive disorder and remains a leading cause of maternal and perinatal morbidity and mortality worldwide. Although abnormal placentation, impaired trophoblast invasion, endothelial dysfunction, and immune dysregulation have been implicated in its pathogenesis, the underlying molecular mechanisms are not fully understood.
Progesterone plays a critical role in the maintenance of pregnancy through both classical nuclear receptors and membrane-associated progesterone receptors. Emerging eviden...