Clinical Trial: Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission

U.S., April 7 -- ClinicalTrials.gov registry received information related to the study (NCT07511439) titled 'Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission' on March 28.

Brief Summary: The goal of this study is to learn about potential reversible effects of combined oral contraceptive (COC) use on the serotonergic brain system. The main question it aims to answer is:

- If COC discontinuation results in an increase in serotonin 4 receptor binding in caudate, putamen, and hippocampus measured with Positron Emission Tomography from baseline to follow-up >= week 8 after discontinuation.

The secondary question it aims to answer is:

- Over what timeframe the serotonin 4 receptor binding is restored after CO...