U.S., June 3 -- ClinicalTrials.gov registry received information related to the study (NCT07620782) titled 'Response Surface Modeling of Remimazolam and Sevoflurane' on May 14.
Brief Summary: This prospective randomized open-label study aims to investigate the pharmacodynamic interaction between remimazolam and sevoflurane during general anesthesia using response surface modeling. Although remimazolam has favorable hemodynamic stability compared with propofol, its hypnotic effect may be less predictable and poorly correlated with conventional sedation monitoring indices such as the bispectral index (BIS). In clinical practice, remimazolam and sevoflurane are often combined during induction and maintenance of anesthesia; however, the optima...