U.S., July 31 -- ClinicalTrials.gov registry received information related to the study (NCT07736495) titled 'Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis' on July 26.
Brief Summary: Colorectal cancer (CRC) represents one of the most common cancers worldwide and 5-Fluorouracil (5-FU) is still the mainstay of treatment. However, 5-FU is often implicated in inducing oral mucositis (OM), a painful inflammatory condition that may hinder oral intake, negatively impact quality of life and disrupt adherence with cancer treatment.
Oxidative stress and inflammation play a vital role in OM pathogenesis. Alpha-lipoic acid (ALA) is a powerful antioxidant and anti-inflammatory agent that has demonstrated protective effects tow...