U.S., Jan. 31 -- ClinicalTrials.gov registry received information related to the study (NCT07378371) titled 'Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium' on Jan. 18.
Brief Summary: This randomized controlled trial evaluates the efficacy of a proactive Goal-Directed Temperature Management (GDTM) protocol in reducing postoperative delirium among patients undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for pseudomyxoma peritonei.
CRS-HIPEC presents a unique physiological challenge characterized by a biphasic thermal trajectory: potential hypothermia during extensive surgery followed by rapid iatrogenic hyperthermia during perfusion. This study compares a standardized ...