Clinical Trial: Pragmatic Phase II Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Oncotype DX and Abemaciclib

U.S., Feb. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07428018) titled 'Pragmatic Phase II Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Oncotype DX and Abemaciclib' on Feb. 17.

Brief Summary: This is a pragmatic phase 2 study to determine the proportion of patients with ER+ (>=10%)/HER2- EBC in whom neoadjuvant chemotherapy can be replaced by NET plus abemaciclib based on the results of the ODX RS obtained in the initial diagnostic biopsy and according to the MDT decision and to evaluate the proportion of patients undergoing breast conservative surgery and/or sentinel node biopsy

Study Start Date: April 30

Study Type: INTERVENTIONAL

Conditi...