Clinical Trial: Plasma ctDNA Monitoring in Pediatric Acute Leukemia

U.S., Aug. 8 -- ClinicalTrials.gov registry received information related to the study (NCT07751588) titled 'Plasma ctDNA Monitoring in Pediatric Acute Leukemia' on July 21.

Brief Summary: This retrospective-prospective observational cohort study aims to evaluate peripheral blood plasma circulating tumor DNA (ctDNA) dynamics in pediatric acute leukemia and compare ctDNA results with concurrent bone marrow multiparameter flow cytometry minimal residual disease (MFC-MRD), droplet digital PCR (ddPCR), and RNA sequencing findings. The study includes a retrospective cohort with available clinical and molecular data and a prospective cohort with serially collected peripheral blood and bone marrow samples at predefined treatment time points. The s...