Clinical Trial: Pilot Deprescribing of Antimuscarinic Overactive Bladder Medications in Parkinson Disease

U.S., June 5 -- ClinicalTrials.gov registry received information related to the study (NCT07627529) titled 'Pilot Deprescribing of Antimuscarinic Overactive Bladder Medications in Parkinson Disease' on May 08.

Brief Summary: This is an unblinded, non-randomized National Institute of Health (NIH) Stage I of Behavioral Intervention Development trial. The investigators will enroll 20 subjects with Parkinson disease (PD) for a series of 20 of N-of-1 trials. The investigators will use a single-arm crossover titration/reversal design ("ON" [A] vs. "OFF" [B]) with up to 4 periods. All participants will follow the sequence ABAB. Each period will last up to 10 weeks, allowing for sufficient time for up-titration and onset of drug action, and down-t...