Clinical Trial: Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance

U.S., Aug. 13 -- ClinicalTrials.gov registry received information related to the study (NCT07759336) titled 'Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance' on July 24.

Brief Summary: The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking ability in patients with knee osteoarthritis. At study visits, participants will complete surveys, perform physical function tasks, undergo non-invasive brain imaging, and undergo sensory testing.

Study Start Date: Aug., 2026

Stud...