U.S., July 3 -- ClinicalTrials.gov registry received information related to the study (NCT07681063) titled 'Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery' on June 11.
Brief Summary: Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life. Growing evidence suggests that neuroinflammation plays a relevant role in POCD development and persistence.
Palmitoylethanolamide (PEA) is an endogenous lipid mediator involved in the regulation of neuroinflammatory processes through the modulation of non-neuronal cells, while luteolin is a flavo...