U.S., June 23 -- ClinicalTrials.gov registry received information related to the study (NCT07658989) titled 'Optimizing Anticoagulation in Pregnancies With Mechanical Heart Valves' on Nov. 26, 2025.
Brief Summary: The purpose of this pilot study is to collect data on pregnancies with mechanical heart valves to see if using a blood thinner called low molecular weight heparin (LMWH) and low dose aspirin (LDA) is comparable to warfarin/vitamin K antagonist (VKA) to reduce the chance of clotting around the mechanical valve and improve survival. The study is a pilot study as the study investigators need to ensure that the blood levels needed for adequate amounts of LMWH and warfarin can be maintained during pregnancy to be able to compare LMWH ...