Clinical Trial: Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical Mastectomy

U.S., Sept. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07798895) titled 'Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical Mastectomy' on Aug. 28.

Brief Summary: This randomized controlled trial compares opioid-free anesthesia combined with pectoral nerve block (PECS I and II) with opioid-based anesthesia in patients undergoing modified radical mastectomy. The study evaluates postoperative CD4+ T-cell counts as a marker of cellular immune response, as well as postoperative pain intensity and nausea and vomiting. Twenty-eight patients were randomly assigned to receive either opioid-free anesthesia with PECS I and II block or opioid-based anesthesia with fentanyl. CD4+ T-cell counts were asses...