Clinical Trial: Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.

U.S., Jan. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07353372) titled 'Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.' on Dec. 29, 2025.

Brief Summary: This multicenter, assessor-blinded, two-arm parallel randomized controlled trial (N = 314) will compare the efficacy and safety of a 6-week multidimensional exercise program plus usual pharmacological care (experimental arm) versus usual pharmacological care alone (control arm) in adults >= 60 years with chronic non-specific low-back pain (LBP) and imaging evidence of paraspinal muscle degeneration. The primary endpoint is change in Oswestry Disability Index (ODI) at 12 months. Secondary endpoints include pain VA...