U.S., May 20 -- ClinicalTrials.gov registry received information related to the study (NCT07596615) titled 'Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence' on April 29.
Brief Summary: The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups. Skin-derived fibroblasts and peripheral blood mononuclear cells (PBMCs) will be isolated from skin biopsy and blood samples to characterize age-related cellular and molecular changes and to test experimental therapeutic strategies identified in preclinical studies. Serum, plasma, and whole-blood RNA will be used for protocol...