Clinical Trial: Microbiota Changes Related to Outcomes in Kidney Transplantation

U.S., Oct. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07893691) titled 'Microbiota Changes Related to Outcomes in Kidney Transplantation' on Oct. 19.

Brief Summary: Chronic kidney disease affects approximately 10% of the world population. End-stage renal disease (ESRD) is associated with immune dysregulation, chronic inflammation, and alteration of the gut and urinary microbiota. Kidney transplantation is the reference treatment for ESRD, but required immunosuppressive therapy further aggravates immune dysregulation and is associated with cardiovascular, metabolic and infectious complications. The gut microbiota plays a central role in modulating systemic immunity. In ESRD, microbiota composition is str...