Clinical Trial: Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS

U.S., Aug. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07138274) titled 'Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS' on July 24.

Brief Summary: single-center, randomized, double-blind, placebo-controlled Phase 2 study to evaluate safety and efficacy of overnight metyrapone in patients with MACS.

Study Start Date: April, 2026

Study Type: INTERVENTIONAL

Condition: Mild Autonomous Cortisol Secretion (MACS) Autonomous Cortisol Secretion (ACS)

Intervention: DRUG: Metyrapone 250 mg Oral Tablets

Subjects will receive metyrapone beginning at 500 mg and titrating up to 1000 mg

DRUG: Placebo

Subjects will receive placebo at 500 mg dose and titrated up to 1000 mg...