Clinical Trial: Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis

U.S., April 10 -- ClinicalTrials.gov registry received information related to the study (NCT07520110) titled 'Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis' on April 02.

Brief Summary: This is a randomized, placebo-controlled trial of metformin in 400 participants with idiopathic pulmonary fibrosis (IPF) who are at high risk of adverse clinical outcomes based on a proteomic classifier. The primary objective is to assess the safety and efficacy of metformin compared to placebo in participants with IPF who are at high-risk for adverse clinical events.

Approximately 800 participants with IPF will be screened. 400 participants who are at high risk for adverse clinical events (proteomic signature prese...