U.S., June 2 -- ClinicalTrials.gov registry received information related to the study (NCT07617922) titled 'Melatonin and Solifenacin for Double-J Ureteral Stent Symptoms' on May 25.
Brief Summary: Double-J ureteral stents are commonly inserted after ureteroscopy, but they may cause bothersome urinary symptoms, pain, sleep disturbance, and reduced quality of life.
This prospective randomized assessor-blinded three-arm clinical trial will compare oral solifenacin, oral melatonin, and their combination for improving ureteral stent-related symptoms in adult patients after unilateral ureteroscopic lithotripsy with insertion of a unilateral Double-J ureteral stent.
Participants will be randomized to receive solifenacin 5 mg once daily, melato...