Clinical Trial: Mechanistic Evaluation of Polypharmacy Effects for Pain

U.S., Sept. 30 -- ClinicalTrials.gov registry received information related to the study (NCT07846020) titled 'Mechanistic Evaluation of Polypharmacy Effects for Pain' on Sept. 14.

Brief Summary: This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid) when the two are combined.

Study Start Date: Jan. 15, 2027

Study Type: INTERVENTIONAL

Condition: Chronic Lower Back Pain (CLBP)

Intervention: DRUG: Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin)

Within-subject double-blind, double-dummy, study design wherein all participants rece...