U.S., Sept. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07813936) titled 'Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis' on Sept. 06.
Brief Summary: Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response. This inflammatory process leads to the excessive production of reactive oxygen species (ROS), causing oxidative stress and tissue damage. Melatonin is a potent antioxidant and immunomodulator that scavenges free radicals and reduces inflammation. Previous research indicates that salivary and gingival crevicular fluid (GCF) me...