Clinical Trial: LME-Guided Precision Combination Therapy in B-cell Lymphoma Patients After CD19 CAR-T Failure

U.S., May 23 -- ClinicalTrials.gov registry received information related to the study (NCT07602322) titled 'LME-Guided Precision Combination Therapy in B-cell Lymphoma Patients After CD19 CAR-T Failure' on May 15.

Brief Summary: This study evaluates a personalized treatment strategy for patients with large B-cell lymphoma (LBCL) whose disease has relapsed or not responded after CD19 CAR-T cell therapy. Researchers believe that the area surrounding the tumor, called the lymphoma microenvironment (LME), plays a major role in why treatments fail.

In this study, researchers will classify patients into four different LME subtypes (GC, IN, ME, or DE) using a standard lab test on their tumor samples. Patients will then be randomly assigned to on...