U.S., May 14 -- ClinicalTrials.gov registry received information related to the study (NCT07585123) titled 'L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0' on May 06.
Brief Summary: Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are debilitating complications following dental extractions in patients who have received head and neck radiotherapy or antiresorptive therapy. These conditions are associated with significant morbidity, including persistent pain, poor oral function, and reduced quality of life.
While preventive strategies remain limited, platelet-rich fibrin (L-PRF), an autologous fibrin matrix enriched with growth factors, has shown potential in promoting wound healing and...