Clinical Trial: Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol Secretion

U.S., June 17 -- ClinicalTrials.gov registry received information related to the study (NCT07649317) titled 'Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol Secretion' on June 13.

Brief Summary: Background:

Cortisol is a hormone in the blood. Cortisol levels normally go down at night and up in the morning. Mild autonomous cortisol secretion (MACS) is a disease in which the body makes too much cortisol. MACS can cause high blood pressure, diabetes, and/or weight gain. Researchers think these problems may be caused by higher cortisol levels at night.

Objective:

To compare daily cortisol levels in people with MACS with those in healthy people. Also, to test a drug (ketoconazole) that may help lower cortisol le...