U.S., May 16 -- ClinicalTrials.gov registry received information related to the study (NCT07590687) titled 'KetAmine and Recovery After Mechanical VentilAtion ( KARMA )' on May 05.
Brief Summary: Invasive mechanical ventilation of critically ill patients in the intensive care unit (ICU) is associated with significant morbidity and mortality, as well as a severe prognosis in survivors, in terms of functional, psychological, and cognitive sequelae. During the initial phase, invasive mechanical ventilation aims to promote oxygenation and reduce respiratory effort, with most patients receiving continuous intravenous sedation comprising gamma-aminobutyric acid (GABA) agonists (propofol, midazolam), and opioids. This continuous intravenous sedat...