Clinical Trial: Induction Chemoimmunotherapy Followed by Deescalated Definitive Radiotherapy in Head and Neck Cancer

U.S., Aug. 29 -- ClinicalTrials.gov registry received information related to the study (NCT07791602) titled 'Induction Chemoimmunotherapy Followed by Deescalated Definitive Radiotherapy in Head and Neck Cancer' on June 14.

Brief Summary: This study aims to evaluate whether reducing the intensity of radiotherapy (de-escalated radiotherapy) after induction chemoimmunotherapy is not inferior to standard-dose radiotherapy in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). The study is a multicenter, prospective, phase II, randomized, non-inferiority controlled trial. A total of 180 participants who achieve deep tumor response (>=50% regression) after 2-3 cycles of induction chemotherapy plus PD-1 inhibitor (camrel...