U.S., Dec. 31 -- ClinicalTrials.gov registry received information related to the study (NCT07309315) titled 'Inactivated Bacteroides Fragilis for Prevention of Chemotherapy-Induced Diarrhea' on Dec. 12.
Brief Summary: The incidence of chemotherapy-induced diarrhea (CID) is closely related to the types of anticancer drugs. Combination chemotherapy regimens such as fluorouracil derivatives and irinotecan, as well as tyrosine kinase inhibitors like neratinib, are associated with a high severity and incidence of diarrhea. These All antineoplastic agents can induce intestinal epithelial cell apoptosis, damage the intestinal mucosa, subsequently reduce the absorption surface area, and thereby lead to diarrhea. Recent literature has indicated tha...