U.S., June 3 -- ClinicalTrials.gov registry received information related to the study (NCT07622030) titled 'Hydrocortisone Modified-release in Adults: Real-world Monitoring of Longitudinal Outcomes in coNgenital Adrenal hYperplasia' on May 27.
Brief Summary: Classic congenital adrenal hyperplasia (CAH) is an autosomal recessive genetic disorder caused by a defect in the enzyme cascade regulating adrenal steroidogenesis; in approximately 95% of cases the defect is located in CYP21A2, the gene encoding 21-hydroxylase, and is characterized by defective adrenal steroidogenesis and cortisol deficiency. Due to the loss of the physiological feedback of cortisol on the hypothalamus and pituitary corticotropic cells, ACTH secretion is increased. Th...