U.S., Feb. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07419711) titled 'Grape Polyphenols for Prevention of Chemotherapy-Induced Cardiotoxicity' on Feb. 06.
Brief Summary: This pilot randomized clinical study aims to evaluate the cardioprotective effects of a grape polyphenol concentrate in patients receiving anthracycline- and/or trastuzumab-based chemotherapy. Adult patients at high or very high risk of chemotherapy-induced cardiotoxicity will be randomized to receive either a grape polyphenol concentrate or placebo for three months, starting with chemotherapy. Cardiac function and cardiotoxicity will be assessed using echocardiographic parameters and circulating biomarkers at baseline, 3 months, and ...