U.S., Feb. 25 -- ClinicalTrials.gov registry received information related to the study (NCT07428733) titled 'Gene Methylation for Diagnosis of Breast Lesions' on Feb. 04.
Brief Summary: Breast lesions of uncertain malignant potential represent a diagnostic challenge, as conventional histopathological assessment does not always reliably distinguish between benign and malignant changes.
The purpose of this prospective diagnostic study is to evaluate whether methylation patterns of selected breast cancer-related genes (BRCA1, RASSF1A, and PTEN) can help differentiate benign from malignant breast lesions.
Tissue samples obtained during diagnostic needle biopsy, and when applicable during surgical excision, will be analyzed for gene methylati...