U.S., May 2 -- ClinicalTrials.gov registry received information related to the study (NCT07563192) titled 'Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis' on April 11.
Brief Summary: This study investigates the impact of smoking on pyroptosis and inflammatory signaling pathways in systemically healthy individuals with various periodontal conditions. The research compares smokers and non-smokers across three clinical categories, resulting in six study groups: Healthy Control, Gingivitis, and Periodontitis. The study specifically evaluates the levels of IL-1beta, IL-18, and NLRP3 through ELISA, and the gene expression of TLR1, TLR4, and TLR6 through RT-PCR, to understand how cigarette smoke modulates innate imm...