Clinical Trial: Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.

U.S., April 18 -- ClinicalTrials.gov registry received information related to the study (NCT07537517) titled 'Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.' on April 09.

Brief Summary: Previous data from our group showed reduced BMPR2 isoform A in pulmonary hypertension associated with left heart disease (PH-LHD) of valvular origin.

Focusing on dysregulation of the BMPR2-activin pathway, a key regulator of vascular homeostasis, this project uses a multimodal approach combining molecular biology, advanced cardiac imaging, and histology.

Its aim is to determine the role of the BMPR2-activin pathway in the development and regression of PH-LHD.

We will conduct a prospective observational study with 1-...