U.S., Aug. 29 -- ClinicalTrials.gov registry received information related to the study (NCT07146997) titled 'Evaluating the Combined Effect of Oral Premedications on Inferior Alveolar Nerve Block Effectiveness' on Aug. 13.
Brief Summary: This clinical study investigates whether the combination of ibuprofen and serratiopeptidase as oral premedication can enhance the effectiveness of the inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular teeth. Due to the inflammatory nature of the condition, standard IANB often fails, possibly due to prostaglandin-induced nerve sensitization.
A total of 96 patients meeting specific inclusion criteria will be divided into four groups:
Placebo
Ibuprofen al...