U.S., Jan. 1 -- ClinicalTrials.gov registry received information related to the study (NCT07312370) titled 'Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing: A Randomized Controlled Trial' on Dec. 17, 2025.
Brief Summary: Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer and precancerous lesions. Post-ESD artificial ulcers may lead to complications including delayed bleeding (3-15%) and prolonged healing. Current guidelines recommend high-dose proton pump inhibitors (PPIs), but evidence for additional mucosal protective agents remains limited.
This study aims to evaluate whether combining sucralfate suspension with standard intravenous esomeprazole therapy improves ulcer healing and reduces...