U.S., Jan. 22 -- ClinicalTrials.gov registry received information related to the study (NCT07356271) titled 'Effects of Mouthwashes on the Oral Microbiome and Systemic Health' on Jan. 12.
Brief Summary: OVERVIEW
While antimicrobial mouthwashes are proven to be clinically effective for management of certain oral microbial diseases, recent studies (Bescos et al 2025, Gallard et al 2025) suggest tha, in addition to targeting bacteria responsible for gum diseases such as gingivitis and periodontitis, they may harm healthy bacteria and disturb the balance and protective role of the oral microbiome (dysbiosis).
Most findings on the oral microbiome and mouthwashes involve chlorhexidine use, demonstrating that it may induce dysbiosis and comprom...