Clinical Trial: Effectiveness of Enzyme Spray Intervention on Thirst Relief in Patients With Endotracheal Intubation.

U.S., April 17 -- ClinicalTrials.gov registry received information related to the study (NCT07533552) titled 'Effectiveness of Enzyme Spray Intervention on Thirst Relief in Patients With Endotracheal Intubation.' on April 10.

Brief Summary: This study addresses the high prevalence (66%-70%) of thirst among intensive care unit (ICU) patients with endotracheal intubation, a symptom associated with oral mucosal dryness, nil per os (NPO) status, high-flow oxygen therapy, and medication effects. Unrelieved thirst may contribute to anxiety, delirium, and unplanned extubation. Current clinical practices, such as cold water or saline sprays, provide only transient relief and may pose aspiration risks. Enzyme-based saliva substitutes, which mimic n...