Clinical Trial: Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers

U.S., Oct. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07860515) titled 'Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers' on Sept. 03.

Brief Summary: Passive leg raising (PLR) transiently increases venous return and cardiac preload and is commonly used to predict fluid responsiveness in critically ill patients. Repeated fluid boluses contribute to fluid overload in septic shock, whereas PLR may provide similar hemodynamic effects without fluid administration.

Before evaluating repeated PLR in septic shock patients, it is necessary to determine whether the cardiac output response to PLR remains present during repeated PLR maneuvers.

SYSLE-1 is a prospective inter...