U.S., Dec. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07293234) titled 'Effect of Simethicone on Helicobacter Pylori Detection in Routine Endoscopy' on Dec. 17.
Brief Summary: Rationale: Although simethicone improves mucosal clarity, in vitro evidence suggests that its surfactant properties may disrupt bacterial adherence or viability. These findings raise concerns that simethicone may negatively affect the sensitivity of endoscopic-based H. pylori diagnostic methods. To date, no prospective in vivo study has evaluated whether simethicone influences H. pylori detection through endoscopic sampling. This randomized paired trial is designed to address this gap in evidence and evaluate whether simethicone a...