U.S., Feb. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07426042) titled 'Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects' on Dec. 31, 2025.
Brief Summary: Purpose:
The purpose of this study is to understand how dexamethasone affects the activity of drug-metabolizing enzymes in the body and how this may influence interactions with other medicines, such as voriconazole.
Background:
Many medicines are broken down in the body by enzymes called cytochrome P450 (CYP) enzymes. Differences in CYP enzyme activity between individuals can lead to variability in drug response and drug-drug interactions. Dexamethasone is known to affect CYP enzyme activity, and voriconazole is a medication ...