U.S., April 21 -- ClinicalTrials.gov registry received information related to the study (NCT07539012) titled 'Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy' on April 13.
Brief Summary: Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. It results from the accumulation of guttae and progressive loss of corneal endothelial cells, leading to corneal edema and visual impairment. Endothelial keratoplasty remains the reference treatment, but graft shortages have promoted the development of cell-based therapies involving the injection of cultured endothelial cells. A key unresolved issue is whether removal of the pathological endothelium prior to injection imp...