Clinical Trial: DNP-MRSI of HCC Metabolism to Predict Therapeutic Response

U.S., Sept. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07807475) titled 'DNP-MRSI of HCC Metabolism to Predict Therapeutic Response' on Sept. 02.

Brief Summary: This proposal describes a non-therapeutic diagnostic clinical trial to estimate the ability of DNP-MRS imaging of hyperpolarized 1-13C-pyruvate uptake and metabolism to predict response following LRT with TACE/TARE/Microwave Ablation or ST in patients with Barcelona Clinic Liver Cancer (BCLC) stage A, B or C HCC. The primary hypothesis is that intratumoral pyruvate, lactate, alanine and carbon dioxide/bicarbonate measured by DNP-MRSI correspond to cellular viability resulting from recurrent or progressive HCC following LRT or ST. The secondary hy...