U.S., June 13 -- ClinicalTrials.gov registry received information related to the study (NCT07646054) titled 'Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers' on June 02.
Brief Summary: Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged 60-80 with APOE4 positivity or elevated polygenic risk. Participants are recruited through 23andMe and enrolled via the MyDataHelps platform. Following genetic eligibility screening, 1,200 participants will be randomized to either a digital lifestyle coaching arm (UCardia) or an education-only control ...