U.S., Sept. 25 -- ClinicalTrials.gov registry received information related to the study (NCT07838064) titled 'Detection of Biomarkers for Prosthetic Infection Type - (DEBIT)' on June 26.
Brief Summary: Prosthetic joint infection (PJI) is a significant cause of failure in hip and knee arthroplasty and is often difficult to diagnose using current methods. This study aims to identify novel biomarkers for early and accurate diagnosis of PJI using nanopore sequencing technology (Oxford Nanopore Technologies). By analysing microbial profiles and host immune responses in samples from patients undergoing revision surgery, the study will compare infected and non-infected cases. Biomarkers will be investigated in periprosthetic tissue as well as les...