U.S., Oct. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07217912) titled 'Daridorexant to Prevent Post-cardiotomy Delirium' on Oct. 14.
Brief Summary: The goal of this follow-on pilot randomized clinical trial is to obtain additional preliminary data to inform a larger, adequately powered phase 2b trial of daridorexant for the prevention of postoperative delirium after heart surgery. Having demonstrated feasibility in a prior study (RSRB #9841), this study aims to estimate the effect of daridorexant on (1) reducing delirium symptom burden and incidence and (2) improving sleep quality during the postoperative period, and (3) to assess the feasibility of collecting audiovisual data before surgery for natura...