Clinical Trial: Cytokine Response to Abdominal Wall Reconstruction

U.S., Feb. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07422584) titled 'Cytokine Response to Abdominal Wall Reconstruction' on Feb. 04.

Brief Summary: This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure.

The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be...