Clinical Trial: Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor

U.S., Aug. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07743554) titled 'Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor' on July 30.

Brief Summary: The purpose of this study is to learn whether the study drugs avutometinib and defactinib can help stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery.

Study Start Date: Jan. 01, 2027

Study Type: INTERVENTIONAL

Condition: MPNST (Malignant Peripheral Nerve Sheath Tumor)

Intervention: DRUG: avutometinib capsule + defactinib tablet

avutometinib in combination with defactinib in participants ...