U.S., May 6 -- ClinicalTrials.gov registry received information related to the study (NCT07567222) titled 'Clinical Study of Novel Therapeutic Vaccine for Advanced Solid Tumors' on April 20.
Brief Summary: Advanced solid tumors remain a major therapeutic challenge due to their complex heterogeneity and the immunosuppressive tumor microenvironment (TME). Although cancer vaccines are designed to induce long-lasting antitumor immunity, their efficacy is often limited by the TME's immune-evasive mechanisms.
Building on this rationale, investigators developed a novel vaccine comprising irradiated tumor cells and stromal cells isolated from adjacent non-cancerous tissues or tumor tissues in combination with adjuvant. Irradiated tumor cells in v...