U.S., Dec. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07304193) titled 'Clinical and Genetic Aspects of Fetuses With Sex-chromosome Disorders' on Dec. 12.
Brief Summary: To conduct a comprehensive clinical investigation of electively aborted fetuses with sex chromosome disorders and their placentas, in parallel with analyses of epigenetic alterations and changes in gene expression in these fetuses and their placentas, with the aims to:
1. delineate how variations in sex chromosome number affect the epigenetic and genetic mechanisms regulating gene expression in the placenta and in multiple fetal tissues in fetuses with sex chromosome disorders;
2. identify the epigenetic and genetic mechanisms and pla...