U.S., July 14 -- ClinicalTrials.gov registry received information related to the study (NCT07698470) titled 'Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use' on June 26, 2025.
Brief Summary: Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smoking-related cues using functional near-infrared spectroscopy (fNIRS). Participants will complete assessments before and after nicotine po...