U.S., April 1 -- ClinicalTrials.gov registry received information related to the study (NCT07503743) titled 'Biology-Driven Cognitive Profiling in Huntington's Disease' on Nov. 28, 2025.
Brief Summary: Huntington's disease (HD) is a genetic, progressive neurodegenerative disorder characterized by early and widespread brain changes that can begin more than a decade before the onset of unequivocal motor signs. Although biological indicators of neurodegeneration-including striatal and cortical atrophy, white-matter disruption, and elevated plasma and CSF biomarkers-are detectable during the premanifest stage, cognitive performance typically appears within normal limits when assessed with conventional neuropsychological instruments.
In sympto...